Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos

Insufficient membrane penetration of drugs, in particular biotherapeutics and/or low target specificity remain a major drawback in their efficacy. We propose here the rational characterization and optimization of peptides to be developed as vectors that target cells expressing specific receptors inv...

Descripción completa

Detalles Bibliográficos
Autores principales: David, Marion, Lécorché, Pascaline, Masse, Maxime, Faucon, Aude, Abouzid, Karima, Gaudin, Nicolas, Varini, Karine, Gassiot, Fanny, Ferracci, Géraldine, Jacquot, Guillaume, Vlieghe, Patrick, Khrestchatisky, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828360/
https://www.ncbi.nlm.nih.gov/pubmed/29485998
http://dx.doi.org/10.1371/journal.pone.0191052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828360/
https://www.ncbi.nlm.nih.gov/pubmed/29485998
http://dx.doi.org/10.1371/journal.pone.0191052

Ejemplares similares