Cargando…
Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos
Insufficient membrane penetration of drugs, in particular biotherapeutics and/or low target specificity remain a major drawback in their efficacy. We propose here the rational characterization and optimization of peptides to be developed as vectors that target cells expressing specific receptors inv...
Autores principales: | David, Marion, Lécorché, Pascaline, Masse, Maxime, Faucon, Aude, Abouzid, Karima, Gaudin, Nicolas, Varini, Karine, Gassiot, Fanny, Ferracci, Géraldine, Jacquot, Guillaume, Vlieghe, Patrick, Khrestchatisky, Michel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828360/ https://www.ncbi.nlm.nih.gov/pubmed/29485998 http://dx.doi.org/10.1371/journal.pone.0191052 |
Ejemplares similares
-
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma
por: Acier, Angélina, et al.
Publicado: (2021) -
Lipoprotein Particles as Shuttles for Hydrophilic Cargo
por: Weber, Florian, et al.
Publicado: (2023) -
Versatile Loading of Diverse Cargo into Functional Polymer Capsules
por: Richardson, Joseph J., et al.
Publicado: (2015) -
Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Endocytic Clearance of Tissue Inhibitor of Metalloproteinases-1 and Promotes Its Cytokine-Like Activities
por: Thevenard, Jessica, et al.
Publicado: (2014) -
Receptor-Independent Transfer of Low Density Lipoprotein
Cargo to Biomembranes
por: Axmann, Markus, et al.
Publicado: (2019)