Kynurenic acid accumulation underlies learning and memory impairment associated with aging

A general feature of animal aging is decline in learning and memory. Here we show that in Caenorhabditis elegans, a significant portion of this decline is due to accumulation of kynurenic acid (KYNA), an endogenous antagonist of neural N-methyl-D-aspartate receptors (NMDARs). We show that activation...

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Detalles Bibliográficos
Autores principales: Vohra, Mihir, Lemieux, George A., Lin, Lin, Ashrafi, Kaveh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828390/
https://www.ncbi.nlm.nih.gov/pubmed/29386332
http://dx.doi.org/10.1101/gad.307918.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828390/
https://www.ncbi.nlm.nih.gov/pubmed/29386332
http://dx.doi.org/10.1101/gad.307918.117

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