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Kynurenic acid accumulation underlies learning and memory impairment associated with aging
A general feature of animal aging is decline in learning and memory. Here we show that in Caenorhabditis elegans, a significant portion of this decline is due to accumulation of kynurenic acid (KYNA), an endogenous antagonist of neural N-methyl-D-aspartate receptors (NMDARs). We show that activation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828390/ https://www.ncbi.nlm.nih.gov/pubmed/29386332 http://dx.doi.org/10.1101/gad.307918.117 |
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author | Vohra, Mihir Lemieux, George A. Lin, Lin Ashrafi, Kaveh |
author_facet | Vohra, Mihir Lemieux, George A. Lin, Lin Ashrafi, Kaveh |
author_sort | Vohra, Mihir |
collection | PubMed |
description | A general feature of animal aging is decline in learning and memory. Here we show that in Caenorhabditis elegans, a significant portion of this decline is due to accumulation of kynurenic acid (KYNA), an endogenous antagonist of neural N-methyl-D-aspartate receptors (NMDARs). We show that activation of a specific pair of interneurons either through genetic means or by depletion of KYNA significantly improves learning capacity in aged animals even when the intervention is applied in aging animals. KYNA depletion also improves memory. We show that insulin signaling is one factor in KYNA accumulation. |
format | Online Article Text |
id | pubmed-5828390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58283902018-07-01 Kynurenic acid accumulation underlies learning and memory impairment associated with aging Vohra, Mihir Lemieux, George A. Lin, Lin Ashrafi, Kaveh Genes Dev Research Communication A general feature of animal aging is decline in learning and memory. Here we show that in Caenorhabditis elegans, a significant portion of this decline is due to accumulation of kynurenic acid (KYNA), an endogenous antagonist of neural N-methyl-D-aspartate receptors (NMDARs). We show that activation of a specific pair of interneurons either through genetic means or by depletion of KYNA significantly improves learning capacity in aged animals even when the intervention is applied in aging animals. KYNA depletion also improves memory. We show that insulin signaling is one factor in KYNA accumulation. Cold Spring Harbor Laboratory Press 2018-01-01 /pmc/articles/PMC5828390/ /pubmed/29386332 http://dx.doi.org/10.1101/gad.307918.117 Text en © 2018 Vohra et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Communication Vohra, Mihir Lemieux, George A. Lin, Lin Ashrafi, Kaveh Kynurenic acid accumulation underlies learning and memory impairment associated with aging |
title | Kynurenic acid accumulation underlies learning and memory impairment associated with aging |
title_full | Kynurenic acid accumulation underlies learning and memory impairment associated with aging |
title_fullStr | Kynurenic acid accumulation underlies learning and memory impairment associated with aging |
title_full_unstemmed | Kynurenic acid accumulation underlies learning and memory impairment associated with aging |
title_short | Kynurenic acid accumulation underlies learning and memory impairment associated with aging |
title_sort | kynurenic acid accumulation underlies learning and memory impairment associated with aging |
topic | Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828390/ https://www.ncbi.nlm.nih.gov/pubmed/29386332 http://dx.doi.org/10.1101/gad.307918.117 |
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