Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

Although the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes, its regulation is unknown. Here, we show that lipoylation of the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (αKDH) complexes is a dynamically regulated proces...

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Detalles Bibliográficos
Autores principales: Paredes, Felipe, Sheldon, Kely, Lassègue, Bernard, Williams, Holly C., Faidley, Elizabeth A., Benavides, Gloria A., Torres, Gloria, Sanhueza-Olivares, Fernanda, Yeligar, Samantha M., Griendling, Kathy K., Darley-Usmar, Victor, San Martin, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828627/
https://www.ncbi.nlm.nih.gov/pubmed/29434038
http://dx.doi.org/10.1073/pnas.1720693115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828627/
https://www.ncbi.nlm.nih.gov/pubmed/29434038
http://dx.doi.org/10.1073/pnas.1720693115

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