Cargando…

Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells

Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity of MTA targets, we analyzed the interaction network in a non-cancerous h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gutiérrez-Escobar, Andrés Julián, Méndez-Callejas, Gina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828656/ https://www.ncbi.nlm.nih.gov/pubmed/29246518 http://dx.doi.org/10.1016/j.gpb.2017.04.006

Ejemplares similares

Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells
por: Delgado-Carreño, Claudia, et al.
Publicado: (2019)

Rapid evolution of the Helicobacter pylori AlpA adhesin in a high gastric cancer risk region from Colombia
por: Gutiérrez-Escobar, Andrés Julián, et al.
Publicado: (2018)

Xenopus Meiotic Microtubule-Associated Interactome
por: Gache, Vincent, et al.
Publicado: (2010)

A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis
por: Hughes, Julian R, et al.
Publicado: (2008)

Novel microtubule-targeting agents – the epothilones
por: Cheng, Kit L, et al.
Publicado: (2008)

Beyond taxanes: the next generation of microtubule-targeting agents
por: Cortes, Javier, et al.
Publicado: (2011)

Recent Approaches to the Identification of Novel Microtubule-Targeting Agents
por: Eli, Susanna, et al.
Publicado: (2022)

Quantitative interactome analysis reveals a chemoresistant edgotype
por: Chavez, Juan D., et al.
Publicado: (2015)

The novel compound STK405759 is a microtubule-targeting agent with potent and selective cytotoxicity against multiple myeloma in vitro and in vivo
por: Rozic, Gabriela, et al.
Publicado: (2016)

The EHEC-host interactome reveals novel targets for the translocated intimin receptor
por: Blasche, Sonja, et al.
Publicado: (2014)

APID interactomes: providing proteome-based interactomes with controlled quality for multiple species and derived networks
por: Alonso-López, Diego, et al.
Publicado: (2016)

Cell Cycle Regulation of Microtubule Interactomes: Multi-layered Regulation Is Critical for the Interphase/Mitosis Transition
por: Syred, Heather M., et al.
Publicado: (2013)

Microtubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma
por: Loong, Herbert H, et al.
Publicado: (2014)

Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles
por: Wordeman, Linda, et al.
Publicado: (2021)

A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization activity
por: De Abreu, Isadora Rocha, et al.
Publicado: (2023)

An actin remodeling role for Arabidopsis processing bodies revealed by their proximity interactome
por: Liu, Chen, et al.
Publicado: (2023)

Identifying candidate agents for lung adenocarcinoma by walking the human interactome
por: Sun, Yajiao, et al.
Publicado: (2016)

Landscape of the Plasmodium Interactome Reveals Both Conserved and Species-Specific Functionality
por: Hillier, Charles, et al.
Publicado: (2019)

Haploid genetic screens identify genetic vulnerabilities to microtubule‐targeting agents
por: Gerhards, Nora M., et al.
Publicado: (2018)

Regulating the BCL2 Family to Improve Sensitivity to Microtubule Targeting Agents
por: Whitaker, Robert H., et al.
Publicado: (2019)

Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy
por: Sato-Kaneko, Fumi, et al.
Publicado: (2018)

Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
por: Tomar, Vartika, et al.
Publicado: (2019)

Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana
por: Van Leene, Jelle, et al.
Publicado: (2010)

Quantitative single-cell interactomes in normal and virus-infected mouse lungs
por: Cain, Margo P., et al.
Publicado: (2020)

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells
Publicado: (1982)

Applying systems-level spectral imaging and analysis to reveal the organelle interactome
por: Valm, Alex M., et al.
Publicado: (2017)

Subcellular Localization and Mitotic Interactome Analyses Identify SIRT4 as a Centrosomally Localized and Microtubule Associated Protein
por: Bergmann, Laura, et al.
Publicado: (2020)

Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism
por: Markowitz, Daniel, et al.
Publicado: (2017)

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent
por: Jost, Marco, et al.
Publicado: (2017)

Schizophrenia interactome: fully-labeled interactome network
por: Ganapathiraju, Madhavi, et al.
Publicado: (2016)

Peptide array–based interactomics
por: Hernandez, Daniel Perez, et al.
Publicado: (2021)

Rigidity of microtubules is increased by stabilizing agents
Publicado: (1995)

Taxol(®): The First Microtubule Stabilizing Agent
por: Yang, Chia-Ping Huang, et al.
Publicado: (2017)

Revealing Missing Parts of the Interactome via Link Prediction
por: Hulovatyy, Yuriy, et al.
Publicado: (2014)

GRID-seq reveals the global RNA-chromatin interactome
por: Li, Xiao, et al.
Publicado: (2017)

DTome: a web-based tool for drug-target interactome construction
por: Sun, Jingchun, et al.
Publicado: (2012)

A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity
por: Sirakanyan, Samvel, et al.
Publicado: (2021)

Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster
por: Yu, Kate E., et al.
Publicado: (2018)

Class III β-tubulin expression and in vitro resistance to microtubule targeting agents
por: Stengel, C, et al.
Publicado: (2010)

Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization
por: Choi, Bo-Hwa, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jp4psqifp4msp64o44hn7cfpvq