Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

Human genetic studies have emphasised the dominant contribution of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the islet epigenome has constrained efforts to define the molecular mechanisms mediating the, largely regulatory, signals revealed b...

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Detalles Bibliográficos
Autores principales: Thurner, Matthias, van de Bunt, Martijn, Torres, Jason M, Mahajan, Anubha, Nylander, Vibe, Bennett, Amanda J, Gaulton, Kyle J, Barrett, Amy, Burrows, Carla, Bell, Christopher G, Lowe, Robert, Beck, Stephan, Rakyan, Vardhman K, Gloyn, Anna L, McCarthy, Mark I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828664/
https://www.ncbi.nlm.nih.gov/pubmed/29412141
http://dx.doi.org/10.7554/eLife.31977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828664/
https://www.ncbi.nlm.nih.gov/pubmed/29412141
http://dx.doi.org/10.7554/eLife.31977

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