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Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Pl...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828668/ https://www.ncbi.nlm.nih.gov/pubmed/29436368 http://dx.doi.org/10.7554/eLife.34783 |
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author | Gould, Elizabeth A Busquet, Nicolas Shepherd, Douglas Dietz, Robert M Herson, Paco S Simoes de Souza, Fabio M Li, Anan George, Nicholas M Restrepo, Diego Macklin, Wendy B |
author_facet | Gould, Elizabeth A Busquet, Nicolas Shepherd, Douglas Dietz, Robert M Herson, Paco S Simoes de Souza, Fabio M Li, Anan George, Nicholas M Restrepo, Diego Macklin, Wendy B |
author_sort | Gould, Elizabeth A |
collection | PubMed |
description | Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption. |
format | Online Article Text |
id | pubmed-5828668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58286682018-02-28 Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone Gould, Elizabeth A Busquet, Nicolas Shepherd, Douglas Dietz, Robert M Herson, Paco S Simoes de Souza, Fabio M Li, Anan George, Nicholas M Restrepo, Diego Macklin, Wendy B eLife Neuroscience Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption. eLife Sciences Publications, Ltd 2018-02-13 /pmc/articles/PMC5828668/ /pubmed/29436368 http://dx.doi.org/10.7554/eLife.34783 Text en © 2018, Gould et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Gould, Elizabeth A Busquet, Nicolas Shepherd, Douglas Dietz, Robert M Herson, Paco S Simoes de Souza, Fabio M Li, Anan George, Nicholas M Restrepo, Diego Macklin, Wendy B Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title | Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_full | Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_fullStr | Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_full_unstemmed | Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_short | Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
title_sort | mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828668/ https://www.ncbi.nlm.nih.gov/pubmed/29436368 http://dx.doi.org/10.7554/eLife.34783 |
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