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Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Pl...

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Autores principales: Gould, Elizabeth A, Busquet, Nicolas, Shepherd, Douglas, Dietz, Robert M, Herson, Paco S, Simoes de Souza, Fabio M, Li, Anan, George, Nicholas M, Restrepo, Diego, Macklin, Wendy B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828668/
https://www.ncbi.nlm.nih.gov/pubmed/29436368
http://dx.doi.org/10.7554/eLife.34783
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author Gould, Elizabeth A
Busquet, Nicolas
Shepherd, Douglas
Dietz, Robert M
Herson, Paco S
Simoes de Souza, Fabio M
Li, Anan
George, Nicholas M
Restrepo, Diego
Macklin, Wendy B
author_facet Gould, Elizabeth A
Busquet, Nicolas
Shepherd, Douglas
Dietz, Robert M
Herson, Paco S
Simoes de Souza, Fabio M
Li, Anan
George, Nicholas M
Restrepo, Diego
Macklin, Wendy B
author_sort Gould, Elizabeth A
collection PubMed
description Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.
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spelling pubmed-58286682018-02-28 Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone Gould, Elizabeth A Busquet, Nicolas Shepherd, Douglas Dietz, Robert M Herson, Paco S Simoes de Souza, Fabio M Li, Anan George, Nicholas M Restrepo, Diego Macklin, Wendy B eLife Neuroscience Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function/maintenance is disrupted. Axon disruption occurs in Plp1-null mice as early as 2 months in cortical projection neurons. High-volume cellular quantification techniques revealed a region-specific increase in oligodendrocyte density in the olfactory bulb and rostral corpus callosum that increased during adulthood. A distinct proliferative response of progenitor cells was observed in the subventricular zone (SVZ), while the number and proliferation of parenchymal oligodendrocyte progenitor cells was unchanged. This SVZ proliferative response occurred prior to evidence of axonal disruption. Thus, a novel SVZ response contributes to the region-specific increase in oligodendrocytes in Plp1-null mice. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption. eLife Sciences Publications, Ltd 2018-02-13 /pmc/articles/PMC5828668/ /pubmed/29436368 http://dx.doi.org/10.7554/eLife.34783 Text en © 2018, Gould et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Gould, Elizabeth A
Busquet, Nicolas
Shepherd, Douglas
Dietz, Robert M
Herson, Paco S
Simoes de Souza, Fabio M
Li, Anan
George, Nicholas M
Restrepo, Diego
Macklin, Wendy B
Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_full Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_fullStr Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_full_unstemmed Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_short Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
title_sort mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828668/
https://www.ncbi.nlm.nih.gov/pubmed/29436368
http://dx.doi.org/10.7554/eLife.34783
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