mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism

Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood. Here we report a presynaptic glutamate/cannabinoid mechanism that may un...

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Detalles Bibliográficos
Autores principales: Li, Xia, Peng, Xiao-Qing, Jordan, Chloe J., Li, Jie, Bi, Guo-Hua, He, Yi, Yang, Hong-Ju, Zhang, Hai-Ying, Gardner, Eliot L., Xi, Zheng-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829076/
https://www.ncbi.nlm.nih.gov/pubmed/29487381
http://dx.doi.org/10.1038/s41598-018-22087-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829076/
https://www.ncbi.nlm.nih.gov/pubmed/29487381
http://dx.doi.org/10.1038/s41598-018-22087-1

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