Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion from pancreatic beta cells and suppresses glucagon secretion from alpha cells. It remains controversial, however, whether GLP-1 receptor (GLP-1R) is expressed in mature alpha cells. In this study, unlike previous studies using non-diabetic...

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Detalles Bibliográficos
Autores principales: Nakashima, Koji, Kaneto, Hideaki, Shimoda, Masashi, Kimura, Tomohiko, Kaku, Kohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829082/
https://www.ncbi.nlm.nih.gov/pubmed/29487355
http://dx.doi.org/10.1038/s41598-018-21751-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829082/
https://www.ncbi.nlm.nih.gov/pubmed/29487355
http://dx.doi.org/10.1038/s41598-018-21751-w

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