Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae

To investigate nuclear DNA replication enzymology in vivo, we have studied Saccharomyces cerevisiae strains containing a pol2-16 mutation that inactivates the catalytic activities of DNA polymerase ε (Pol ε). Although pol2-16 mutants survive, they present very tiny spore colonies, increased doubling...

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Detalles Bibliográficos
Autores principales: Garbacz, Marta A., Lujan, Scott A., Burkholder, Adam B., Cox, Phillip B., Wu, Qiuqin, Zhou, Zhi-Xiong, Haber, James E., Kunkel, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829166/
https://www.ncbi.nlm.nih.gov/pubmed/29487291
http://dx.doi.org/10.1038/s41467-018-03270-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829166/
https://www.ncbi.nlm.nih.gov/pubmed/29487291
http://dx.doi.org/10.1038/s41467-018-03270-4

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