NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

PARP-1 cleaves NAD(+) and transfers the resulting ADP-ribose moiety onto target proteins and onto subsequent polymers of ADP-ribose. An allosteric network connects PARP-1 multi-domain detection of DNA damage to catalytic domain structural changes that relieve catalytic autoinhibition; however, the m...

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Detalles Bibliográficos
Autores principales: Langelier, Marie-France, Zandarashvili, Levani, Aguiar, Pedro M., Black, Ben E., Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829251/
https://www.ncbi.nlm.nih.gov/pubmed/29487285
http://dx.doi.org/10.1038/s41467-018-03234-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829251/
https://www.ncbi.nlm.nih.gov/pubmed/29487285
http://dx.doi.org/10.1038/s41467-018-03234-8

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