An ancient conserved role for prion protein in learning and memory

The misfolding of cellular prion protein (PrP(C)) to form PrP Scrapie (PrP(Sc)) is an exemplar of toxic gain-of-function mechanisms inducing propagated protein misfolding and progressive devastating neurodegeneration. Despite this, PrP(C) function in the brain is also reduced and subverted during pr...

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Detalles Bibliográficos
Autores principales: Leighton, Patricia L. A., Nadolski, Nathan J., Morrill, Adam, Hamilton, Trevor J., Allison, W. Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829491/
https://www.ncbi.nlm.nih.gov/pubmed/29358166
http://dx.doi.org/10.1242/bio.025734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829491/
https://www.ncbi.nlm.nih.gov/pubmed/29358166
http://dx.doi.org/10.1242/bio.025734

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