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miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila
Drosophila lethal giant larvae (lgl) encodes a conserved tumor suppressor with established roles in cell polarity, asymmetric division, and proliferation control. Lgl's human orthologs, HUGL1 and HUGL2, are altered in human cancers, however, its mechanistic role as a tumor suppressor remains po...
Autores principales: | Daniel, Scott G., Russ, Atlantis D., Guthridge, Kathryn M., Raina, Ammad I., Estes, Patricia S., Parsons, Linda M., Richardson, Helena E., Schroeder, Joyce A., Zarnescu, Daniela C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829493/ https://www.ncbi.nlm.nih.gov/pubmed/29361610 http://dx.doi.org/10.1242/bio.027391 |
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