An attenuated quadruple gene mutant of Mycobacterium tuberculosis imparts protection against tuberculosis in guinea pigs

Previously we had developed a triple gene mutant of Mycobacterium tuberculosis (MtbΔmms) harboring disruption in three genes, namely mptpA, mptpB and sapM. Though vaccination with MtbΔmms strain induced protection in the lungs of guinea pigs, the mutant strain failed to control the hematogenous spre...

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Detalles Bibliográficos
Autores principales: Bahal, Ritika Kar, Mathur, Shubhita, Chauhan, Priyanka, Tyagi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829500/
https://www.ncbi.nlm.nih.gov/pubmed/29242198
http://dx.doi.org/10.1242/bio.029546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829500/
https://www.ncbi.nlm.nih.gov/pubmed/29242198
http://dx.doi.org/10.1242/bio.029546

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