Directed hydroxyl radical probing reveals Upf1 binding to the 80S ribosomal E site rRNA at the L1 stalk

Upf1 is an SF1-family RNA helicase that is essential for the nonsense-mediated decay (NMD) process in eukaryotes. While Upf1 has been shown to interact with 80S ribosomes, the molecular details of this interaction were unknown. Using purified recombinant proteins and high-throughput sequencing combi...

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Detalles Bibliográficos
Autores principales: Schuller, Anthony P, Zinshteyn, Boris, Enam, Syed Usman, Green, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829565/
https://www.ncbi.nlm.nih.gov/pubmed/29253221
http://dx.doi.org/10.1093/nar/gkx1263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829565/
https://www.ncbi.nlm.nih.gov/pubmed/29253221
http://dx.doi.org/10.1093/nar/gkx1263

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