The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility

Eukaryotic DNA polymerase η catalyzes translesion synthesis of thymine dimers and 8-oxoguanines. It is comprised of a polymerase domain and a C-terminal region, both of which are required for its biological function. The C-terminal region mediates interactions with proliferating cell nuclear antigen...

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Detalles Bibliográficos
Autores principales: Powers, Kyle T, Elcock, Adrian H, Washington, M Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829636/
https://www.ncbi.nlm.nih.gov/pubmed/29385534
http://dx.doi.org/10.1093/nar/gky031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829636/
https://www.ncbi.nlm.nih.gov/pubmed/29385534
http://dx.doi.org/10.1093/nar/gky031

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