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The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility
Eukaryotic DNA polymerase η catalyzes translesion synthesis of thymine dimers and 8-oxoguanines. It is comprised of a polymerase domain and a C-terminal region, both of which are required for its biological function. The C-terminal region mediates interactions with proliferating cell nuclear antigen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829636/ https://www.ncbi.nlm.nih.gov/pubmed/29385534 http://dx.doi.org/10.1093/nar/gky031 |