Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers

Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and tra...

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Detalles Bibliográficos
Autores principales: Sanchez, Gilson J, Richmond, Phillip A, Bunker, Eric N, Karman, Samuel S, Azofeifa, Joseph, Garnett, Aaron T, Xu, Quanbin, Wheeler, Graycen E, Toomey, Cathryn M, Zhang, Qinghong, Dowell, Robin D, Liu, Xuedong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829637/
https://www.ncbi.nlm.nih.gov/pubmed/29240919
http://dx.doi.org/10.1093/nar/gkx1225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829637/
https://www.ncbi.nlm.nih.gov/pubmed/29240919
http://dx.doi.org/10.1093/nar/gkx1225

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