Transcription-induced supercoiling as the driving force of chromatin loop extrusion during formation of TADs in interphase chromosomes

Using molecular dynamics simulations, we show here that growing plectonemes resulting from transcription-induced supercoiling have the ability to actively push cohesin rings along chromatin fibres. The pushing direction is such that within each topologically associating domain (TAD) cohesin rings fo...

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Detalles Bibliográficos
Autores principales: Racko, Dusan, Benedetti, Fabrizio, Dorier, Julien, Stasiak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829651/
https://www.ncbi.nlm.nih.gov/pubmed/29140466
http://dx.doi.org/10.1093/nar/gkx1123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829651/
https://www.ncbi.nlm.nih.gov/pubmed/29140466
http://dx.doi.org/10.1093/nar/gkx1123

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