Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors are necessary. To address this, we used a com...

Descripción completa

Detalles Bibliográficos
Autores principales: Hodel, Karl P, de Borja, Richard, Henninger, Erin E, Campbell, Brittany B, Ungerleider, Nathan, Light, Nicholas, Wu, Tong, LeCompte, Kimberly G, Goksenin, A Yasemin, Bunnell, Bruce A, Tabori, Uri, Shlien, Adam, Pursell, Zachary F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829921/
https://www.ncbi.nlm.nih.gov/pubmed/29488881
http://dx.doi.org/10.7554/eLife.32692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829921/
https://www.ncbi.nlm.nih.gov/pubmed/29488881
http://dx.doi.org/10.7554/eLife.32692

Ejemplares similares