Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice

BACKGROUND: Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate cells (HSCs) in vitro and in a mouse model of liver fibrosis. METHODS: LX2, an...

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Detalles Bibliográficos
Autores principales: Senoo, Takemasa, Sasaki, Ryu, Akazawa, Yuko, Ichikawa, Tatsuki, Miuma, Satoshi, Miyaaki, Hisamitsu, Taura, Naota, Nakao, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830074/
https://www.ncbi.nlm.nih.gov/pubmed/29486718
http://dx.doi.org/10.1186/s12876-018-0761-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830074/
https://www.ncbi.nlm.nih.gov/pubmed/29486718
http://dx.doi.org/10.1186/s12876-018-0761-7

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