The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma

BACKGROUND: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM). This regimen modestly prolongs overall survival, also if, in light of the still dismal prognosis, further improvements are desperately needed, especi...

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Detalles Bibliográficos
Autores principales: Festuccia, Claudio, Mancini, Andrea, Colapietro, Alessandro, Gravina, Giovanni Luca, Vitale, Flora, Marampon, Francesco, Delle Monache, Simona, Pompili, Simona, Cristiano, Loredana, Vetuschi, Antonella, Tombolini, Vincenzo, Chen, Yi, Mehrling, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830080/
https://www.ncbi.nlm.nih.gov/pubmed/29486795
http://dx.doi.org/10.1186/s13045-018-0576-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830080/
https://www.ncbi.nlm.nih.gov/pubmed/29486795
http://dx.doi.org/10.1186/s13045-018-0576-6

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