Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease

BACKGROUND: Accelerated muscle atrophy is associated with a three-fold increase in mortality in chronic kidney disease (CKD) patients. It is suggested that hyperphosphatemia might contribute to muscle wasting, but the underlying mechanisms remain unclear. Although evidence indicates that autophagy i...

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Detalles Bibliográficos
Autores principales: Zhang, Yue-yue, Yang, Man, Bao, Jin-fang, Gu, Li-jie, Yu, Hong-lei, Yuan, Wei-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830092/
https://www.ncbi.nlm.nih.gov/pubmed/29486729
http://dx.doi.org/10.1186/s12882-018-0836-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830092/
https://www.ncbi.nlm.nih.gov/pubmed/29486729
http://dx.doi.org/10.1186/s12882-018-0836-2

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