In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation

T-helper 1 and T-helper 17 lymphocytes mediate acute graft-versus-host disease (GvHD). Interleukin 12 is critical for T-helper 1 differentiation and interleukin 23 for T-helper 17 maintenance. Interleukin 12 and 23 are heterodimeric cytokines that share the p40 subunit (IL-12/IL-23p40). In a randomi...

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Detalles Bibliográficos
Autores principales: Pidala, Joseph, Beato, Francisca, Kim, Jongphil, Betts, Brian, Jim, Heather, Sagatys, Elizabeth, Levine, John E., Ferrara, James L.M., Ozbek, Umut, Ayala, Ernesto, Davila, Marco, Fernandez, Hugo F., Field, Teresa, Kharfan-Dabaja, Mohamed A., Khaira, Divis, Khimani, Farhad, Locke, Frederick L., Mishra, Asmita, Nieder, Michael, Nishihori, Taiga, Perez, Lia, Riches, Marcie, Anasetti, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830373/
https://www.ncbi.nlm.nih.gov/pubmed/29242294
http://dx.doi.org/10.3324/haematol.2017.171199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830373/
https://www.ncbi.nlm.nih.gov/pubmed/29242294
http://dx.doi.org/10.3324/haematol.2017.171199

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