Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H

APOBEC3H (A3H) is a member of the APOBEC3 subfamily of DNA cytosine deaminases that are important for innate immune defense and have been implicated in cancer biogenesis. To understand the structural basis for A3H biochemical function, we determined a high-resolution structure of human A3H and perfo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Fumiaki, Yang, Hanjing, Xiao, Xiao, Li, Shu-Xing, Wolfe, Aaron, Zirkle, Brett, Arutiunian, Vagan, Chen, Xiaojiang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830531/
https://www.ncbi.nlm.nih.gov/pubmed/29491387
http://dx.doi.org/10.1038/s41598-018-21955-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830531/
https://www.ncbi.nlm.nih.gov/pubmed/29491387
http://dx.doi.org/10.1038/s41598-018-21955-0

Ejemplares similares