Cargando…

Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a

The C‐type lectin‐like domain of CLEC14a (CLEC14a‐C‐type lectin‐like domain [CTLD]) is a key domain that mediates endothelial cell–cell contacts in angiogenesis. However, the role of CLEC14a‐CTLD in pathological angiogenesis has not yet been clearly elucidated. In this study, through complementarity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Taek‐Keun, Park, Chang Sik, Jang, Jihye, Kim, Mi Ra, Na, Hee‐Jun, Lee, Kangseung, Kim, Hyun Jung, Heo, Kyun, Yoo, Byong Chul, Kim, Young‐Myeong, Lee, Je‐Wook, Kim, Su Jin, Kim, Eun Sung, Kim, Dae Young, Cha, Kiweon, Lee, Tae Gyu, Lee, Sukmook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830631/ https://www.ncbi.nlm.nih.gov/pubmed/29316206 http://dx.doi.org/10.1002/1878-0261.12169

Ejemplares similares

CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis
por: Jang, Jihye, et al.
Publicado: (2017)

Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis
por: Kim, Taek-Keun, et al.
Publicado: (2017)

Pharmacokinetic evaluation of radiolabeled intraocular anti‐CLEC14a antibody in preclinical animal species and application in humans
por: Park, Sohyun, et al.
Publicado: (2022)

Dickkopf-1 induces angiogenesis via VEGF receptor 2 regulation independent of the Wnt signaling pathway
por: Choi, Sung Hoon, et al.
Publicado: (2017)

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells
por: Lee, Jong-Kuen, et al.
Publicado: (2013)

Endothelial miR-26a regulates VEGF-Nogo-B receptor-mediated angiogenesis
por: Jo, Ha-neul, et al.
Publicado: (2017)

The Role of Vascular Endothelial Growth Factor (VEGF) and p53 Status for Angiogenesis in Gastric Cancer
por: Joo, Young Eun, et al.
Publicado: (2002)

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

Arg-Leu-Tyr-Glu tetrapeptide inhibits tumor progression by suppressing angiogenesis and vascular permeability via VEGF receptor-2 antagonism
por: Baek, Yi-Yong, et al.
Publicado: (2016)

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation
por: Kim, Yeomyeong, et al.
Publicado: (2020)

Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish
por: Pociute, Karolina, et al.
Publicado: (2019)

4-Hexylresorcinol induced angiogenesis potential in human endothelial cells
por: Kim, Min-Keun, et al.
Publicado: (2020)

Antibody-Based Targeting of Cell Surface GRP94 Specifically Inhibits Cetuximab-Resistant Colorectal Cancer Growth
por: Jeoung, Mee Hyun, et al.
Publicado: (2019)

Effects of Mesenchymal Stem Cell Treatment on the Expression of Matrix Metalloproteinases and Angiogenesis during Ischemic Stroke Recovery
por: Nam, Hyo Suk, et al.
Publicado: (2015)

Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals
por: Dai, Wenjuan, et al.
Publicado: (2019)

Paeonol Oxime Inhibits bFGF-Induced Angiogenesis and Reduces VEGF Levels in Fibrosarcoma Cells
por: Lee, Hyo-Jeong, et al.
Publicado: (2010)

Induction of Angiogenesis by Matrigel Coating of VEGF-Loaded PEG/PCL-Based Hydrogel Scaffolds for hBMSC Transplantation
por: Jung, Yeon Joo, et al.
Publicado: (2015)

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation
por: Park, Hyojin, et al.
Publicado: (2015)

Correction: Effects of Mesenchymal Stem Cell Treatment on the Expression of Matrix Metalloproteinases and Angiogenesis during Ischemic Stroke Recovery
por: Nam, Hyo Suk, et al.
Publicado: (2016)

Human Neural Stem Cells Over-Expressing VEGF Provide Neuroprotection, Angiogenesis and Functional Recovery in Mouse Stroke Model
por: Lee, Hong J., et al.
Publicado: (2007)

Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
por: Ha, Jung Min, et al.
Publicado: (2016)

A novel telomerase-derived peptide GV1001-mediated inhibition of angiogenesis: Regulation of VEGF/VEGFR-2 signaling pathways
por: Kim, Jae Hyeon, et al.
Publicado: (2022)

Inhibition of Lewis Lung Carcinoma Growth by Toxoplasma gondii through Induction of Th1 Immune Responses and Inhibition of Angiogenesis
por: Kim, Ju-Ock, et al.
Publicado: (2007)

Crosstalk between angiogenesis and immune regulation in the tumor microenvironment
por: Kim, Hei Jung, et al.
Publicado: (2022)

The antihypertension drug doxazosin inhibits tumor growth and angiogenesis by decreasing VEGFR-2/Akt/mTOR signaling and VEGF and HIF-1α expression
por: Park, Mi Sun, et al.
Publicado: (2014)

Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells
por: Tae, Nara, et al.
Publicado: (2017)

Ex Vivo VEGF Delivery by Neural Stem Cells Enhances Proliferation of Glial Progenitors, Angiogenesis, and Tissue Sparing after Spinal Cord Injury
por: Kim, Hyuk Min, et al.
Publicado: (2009)

VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy
por: Kim, Minah, et al.
Publicado: (2013)

Cannabidiol Suppresses Angiogenesis and Stemness of Breast Cancer Cells by Downregulation of Hypoxia-Inducible Factors-1α
por: Jo, Min Jee, et al.
Publicado: (2021)

Urokinase-derived peptide UP-7 suppresses tumor angiogenesis and metastasis through inhibition of FAK activation
por: Kim, Hyun-Kyung, et al.
Publicado: (2018)

Angiogenesis in Chronic Inflammatory Skin Disorders
por: Lee, Hyun Ji, et al.
Publicado: (2021)

Angiogenesis and vasculogenic mimicry as therapeutic targets in ovarian cancer
por: Lim, Dansaem, et al.
Publicado: (2020)

Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
por: Choi, Sik-Won, et al.
Publicado: (2016)

A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro
por: Kim, Mi Ra, et al.
Publicado: (2017)

A cassaine diterpene alkaloid, 3β-acetyl-nor-erythrophlamide, suppresses VEGF-induced angiogenesis and tumor growth via inhibiting eNOS activation
por: Tae, Nara, et al.
Publicado: (2017)

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
por: Kim, Yunho, et al.
Publicado: (2016)

The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis
por: Chung, Tae-Wook, et al.
Publicado: (2016)

Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway
por: Ha, Jung Min, et al.
Publicado: (2016)

Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis
por: Kim, Hye Young, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_58tttvmtvbp6ckvk2ris94f8uc