A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative

A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound...

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Detalles Bibliográficos
Autores principales: Zhao, Changkuo, Wang, Xianheng, Yang, Fuhong, Gao, Lei, Wang, Yuhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830714/
https://www.ncbi.nlm.nih.gov/pubmed/29515825
http://dx.doi.org/10.1098/rsos.170842
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author Zhao, Changkuo
Wang, Xianheng
Yang, Fuhong
Gao, Lei
Wang, Yuhe
author_facet Zhao, Changkuo
Wang, Xianheng
Yang, Fuhong
Gao, Lei
Wang, Yuhe
author_sort Zhao, Changkuo
collection PubMed
description A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.
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spelling pubmed-58307142018-03-07 A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative Zhao, Changkuo Wang, Xianheng Yang, Fuhong Gao, Lei Wang, Yuhe R Soc Open Sci Chemistry A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines. The Royal Society Publishing 2018-02-14 /pmc/articles/PMC5830714/ /pubmed/29515825 http://dx.doi.org/10.1098/rsos.170842 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Zhao, Changkuo
Wang, Xianheng
Yang, Fuhong
Gao, Lei
Wang, Yuhe
A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
title A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
title_full A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
title_fullStr A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
title_full_unstemmed A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
title_short A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
title_sort simple route to a novel acid-sensitive 20(s)-o-linked camptothecin norcantharidin acid ester derivative
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830714/
https://www.ncbi.nlm.nih.gov/pubmed/29515825
http://dx.doi.org/10.1098/rsos.170842
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