A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines. While AMPKα1 expression is relatively consistent...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Binita, Neilsen, Beth K., Fisher, Kurt W., Gehring, Drew, Hu, Youcai, Volle, Deanna J., Kim, Hyun Seok, McCall, Jamie L., Kelly, David L., MacMillan, John B., White, Michael A., Lewis, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830883/
https://www.ncbi.nlm.nih.gov/pubmed/29491475
http://dx.doi.org/10.1038/s41598-018-22090-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830883/
https://www.ncbi.nlm.nih.gov/pubmed/29491475
http://dx.doi.org/10.1038/s41598-018-22090-6

Ejemplares similares