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Purification of GFRα1+ and GFRα1– Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination

Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface receptor GFRα1. Technical challenges in isolation of GFRα1+ versus GFRα1– undifferentiated spermatogonia have precluded the comparative molecula...

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Detalles Bibliográficos
Autores principales: Garbuzov, Alina, Pech, Matthew F., Hasegawa, Kazuteru, Sukhwani, Meena, Zhang, Ruixuan J., Orwig, Kyle E., Artandi, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830912/
https://www.ncbi.nlm.nih.gov/pubmed/29337115
http://dx.doi.org/10.1016/j.stemcr.2017.12.009