Cargando…

Insulin signaling as a potential natural killer cell checkpoint in fatty liver disease

Insulin resistance is a key risk factor in the progression of nonalcoholic fatty liver disease (NAFLD) and may lead to liver fibrosis. Natural killer (NK) cells are thought to exert an antifibrotic effect through their killing of activated hepatic stellate cells (HSCs). Here, we investigated how the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amer, Johnny, Salhab, Ahmad, Noureddin, Mazen, Doron, Sarit, Abu‐Tair, Lina, Ghantous, Rami, Mahamid, Mahmud, Safadi, Rifaat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831020/ https://www.ncbi.nlm.nih.gov/pubmed/29507903 http://dx.doi.org/10.1002/hep4.1146

Ejemplares similares

Natural Killer Cell-Dependent Anti-Fibrotic Pathway in Liver Injury via Toll-Like Receptor-9
por: Abu-Tair, Lina, et al.
Publicado: (2013)

25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor
por: Salhab, Ahmad, et al.
Publicado: (2020)

Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis
por: Salhab, Ahmad, et al.
Publicado: (2022)

Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions
por: Mahamid, Mahmud, et al.
Publicado: (2011)

The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis
por: Muhanna, Nidal, et al.
Publicado: (2015)

Hepatotoxicity due to tocilizumab and anakinra in rheumatoid arthritis: two case reports
por: Mahamid, Mahmud, et al.
Publicado: (2011)

The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice
por: Fishman, Pnina, et al.
Publicado: (2019)

Low Serum Lysosomal Acid Lipase Activity Correlates with Advanced Liver Disease
por: Shteyer, Eyal, et al.
Publicado: (2016)

Alleviation of Hepatic Steatosis by Alpha-Defensin Is Associated with Enhanced Lipolysis
por: Maraga, Emad, et al.
Publicado: (2023)

Portal lymphadenopathy predicts non-alcoholic steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease
por: Daher, Saleh, et al.
Publicado: (2018)

Efficacy of Birth Dose Vaccination in Preventing Mother-to-Child Transmission of Hepatitis B: A Randomized Controlled Trial Comparing Engerix-B and Sci-B-Vac
por: Safadi, Rifaat, et al.
Publicado: (2021)

Weaker SARS-CoV-2 vaccine responses in nonalcoholic fatty liver disease with advanced liver fibrosis
por: Hakimian, David, et al.
Publicado: (2023)

Advanced Hepatic Fibrosis in Fatty Liver Disease Linked to Hyperplastic Colonic Polyp
por: Mahamid, Mahmud, et al.
Publicado: (2017)

Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling
por: Husanie, Hussam, et al.
Publicado: (2022)

Corrigendum to “Advanced Hepatic Fibrosis in Fatty Liver Disease Linked to Hyperplastic Colonic Polyp”
por: Mahamid, Mahmud, et al.
Publicado: (2017)

Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future
por: Alnimer, Lynna, et al.
Publicado: (2023)

Advanced Liver Fibrosis Correlates With Impaired Efficacy of Pfizer‐BioNTech COVID‐19 Vaccine in Medical Employees
por: Shafrir, Asher, et al.
Publicado: (2022)

The interplay between abdominal aortic aneurysm, metabolic syndrome and fatty liver disease: a retrospective case-control study
por: Mahamid, Mahmud, et al.
Publicado: (2019)

Bloating and Abdominal Distension: Clinical Approach and Management
por: Mari, Amir, et al.
Publicado: (2019)

CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis
por: Greenman, Raanan, et al.
Publicado: (2023)

SARS-CoV-2 vaccine alleviates disease burden and severity in liver transplant recipients even with low antibody titers
por: Khalaileh, Abed, et al.
Publicado: (2023)

The immune and metabolic treatment approach of using testosterone on mice models of liver injury
por: Amer, Johnny, et al.
Publicado: (2023)

Post-infection viral superinfection technology could treat HBV and HCV patients with unmet needs
por: Bakacs, Tibor, et al.
Publicado: (2018)

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease
por: Mato, José M, et al.
Publicado: (2019)

Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells
por: Kim, Nayoung, et al.
Publicado: (2018)

Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28
por: Mariotti, F.R., et al.
Publicado: (2020)

Sphingomyelin is a prospective metabolic immune checkpoint for natural killer cells
por: Ma, Hongdi, et al.
Publicado: (2023)

Malignant deep brain stimulator withdrawal syndrome
por: Azar, Jehad, et al.
Publicado: (2019)

Editorial: Fighting fire with fire: Using non-pathogenic viruses to control unrelated infections
por: Bakacs, Tibor, et al.
Publicado: (2022)

Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy
por: Kwon, Hyung-Joon, et al.
Publicado: (2017)

Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19
por: Demaria, Olivier, et al.
Publicado: (2020)

Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
por: Cao, Yuqing, et al.
Publicado: (2020)

TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity
por: Bi, Jiacheng, et al.
Publicado: (2021)

Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer
por: Buckle, Irina, et al.
Publicado: (2021)

Diet Quality Association with Nonalcoholic Fatty Liver Disease by Cirrhosis Status: The Multiethnic Cohort
por: Park, Song-Yi, et al.
Publicado: (2020)

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Are Correlated with Complicated Diverticulitis and Hinchey Classification: A Simple Tool to Assess Disease Severity in the Emergency Department
por: Mari, Amir, et al.
Publicado: (2019)

Diabetes and Risk of Hepatocellular Carcinoma in Cirrhosis Patients with Nonalcoholic Fatty Liver Disease
por: Teng, Pai-Chi, et al.
Publicado: (2023)

Recurrent deep venous thrombosis in a patient with agenesis of inferior vena cava
por: Nseir, William, et al.
Publicado: (2011)

Case report: successful retreatment of hepatitis C genotype 1b infection with sofosbuvir + simeprevir in a patient with cirrhosis who had prior virologic relapse after treatment with daclatasvir and asunaprevir
por: Safadi, Rifaat, et al.
Publicado: (2016)

Natural killer cells and immune-checkpoint inhibitor therapy: Current knowledge and new challenges
por: Poggi, Alessandro, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e1gpopro1cfm8vmkgk5bf2ov58