Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related a...

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Detalles Bibliográficos
Autores principales: Guo, Yanxia, Walsh, Alice M., Canavan, Mary, Wechalekar, Mihir D., Cole, Suzanne, Yin, Xuefeng, Scott, Brittney, Loza, Mathew, Orr, Carl, McGarry, Trudy, Bombardieri, Michele, Humby, Frances, Proudman, Susanna M., Pitzalis, Costantino, Smith, Malcolm D., Friedman, Joshua R., Anderson, Ian, Madakamutil, Loui, Veale, Douglas J., Fearon, Ursula, Nagpal, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831027/
https://www.ncbi.nlm.nih.gov/pubmed/29489833
http://dx.doi.org/10.1371/journal.pone.0192704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831027/
https://www.ncbi.nlm.nih.gov/pubmed/29489833
http://dx.doi.org/10.1371/journal.pone.0192704

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