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Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression
Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related a...
Autores principales: | Guo, Yanxia, Walsh, Alice M., Canavan, Mary, Wechalekar, Mihir D., Cole, Suzanne, Yin, Xuefeng, Scott, Brittney, Loza, Mathew, Orr, Carl, McGarry, Trudy, Bombardieri, Michele, Humby, Frances, Proudman, Susanna M., Pitzalis, Costantino, Smith, Malcolm D., Friedman, Joshua R., Anderson, Ian, Madakamutil, Loui, Veale, Douglas J., Fearon, Ursula, Nagpal, Sunil |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831027/ https://www.ncbi.nlm.nih.gov/pubmed/29489833 http://dx.doi.org/10.1371/journal.pone.0192704 |
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