Subcellular distribution of ERK phosphorylation in tyrosine and threonine depends on redox status in murine lung cells

Activation of ERK1/2 implies the phosphorylation of tyrosine (pTyr) and threonine (pThr) by MEK1/2; both reactions were thought to be cytoplasmic, promoting ERK to reach the nucleus where it activates several transcription factors. In addition, H(2)O(2) concentrations are known to modulate ERK intra...

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Detalles Bibliográficos
Autores principales: Helfenberger, Katia E., Villalba, Nerina M., Buchholz, Bruno, Boveris, Alberto, Poderoso, Juan José, Gelpi, Ricardo J., Poderoso, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831038/
https://www.ncbi.nlm.nih.gov/pubmed/29489891
http://dx.doi.org/10.1371/journal.pone.0193022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831038/
https://www.ncbi.nlm.nih.gov/pubmed/29489891
http://dx.doi.org/10.1371/journal.pone.0193022

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