Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells

Human pluripotent stem cells (hPSCs) represent a potentially valuable cell source for applications in cell replacement therapy, drug development, and disease modeling. For all these uses, it is necessary to develop reproducible and robust protocols for differentiation into desired cell types. Howeve...

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Detalles Bibliográficos
Autores principales: Fujimori, Koki, Matsumoto, Takuya, Kisa, Fumihiko, Hattori, Nobutaka, Okano, Hideyuki, Akamatsu, Wado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831048/
https://www.ncbi.nlm.nih.gov/pubmed/29107593
http://dx.doi.org/10.1016/j.stemcr.2017.09.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831048/
https://www.ncbi.nlm.nih.gov/pubmed/29107593
http://dx.doi.org/10.1016/j.stemcr.2017.09.024

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