Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination

The nitric oxide (NO)-cyclic GMP pathway contributes to human stem cell differentiation, but NO free radical production can also damage DNA, necessitating a robust DNA damage response (DDR) to ensure cell survival. How the DDR is affected by differentiation is unclear. Differentiation of stem cells,...

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Detalles Bibliográficos
Autores principales: Mujoo, Kalpana, Pandita, Raj K., Tiwari, Anjana, Charaka, Vijay, Chakraborty, Sharmistha, Singh, Dharmendra Kumar, Hambarde, Shashank, Hittelman, Walter N., Horikoshi, Nobuo, Hunt, Clayton R., Khanna, Kum Kum, Kots, Alexander Y., Butler, E. Brian, Murad, Ferid, Pandita, Tej K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831054/
https://www.ncbi.nlm.nih.gov/pubmed/29103969
http://dx.doi.org/10.1016/j.stemcr.2017.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831054/
https://www.ncbi.nlm.nih.gov/pubmed/29103969
http://dx.doi.org/10.1016/j.stemcr.2017.10.002

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