Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model

BACKGROUND: Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels might interfere with CYP-17 expression and histomorphological changes in an and...

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Detalles Bibliográficos
Autores principales: Mahamed, Roberta Rassi, Maganhin, Carla Cristina, Sasso, Gisela Rodrigues Silva, de Jesus Simões, Manuel, Baracat, Maria Candida Pinheiro, Baracat, Edmund Chada, Soares-, José Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831207/
https://www.ncbi.nlm.nih.gov/pubmed/29490689
http://dx.doi.org/10.1186/s13048-018-0392-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831207/
https://www.ncbi.nlm.nih.gov/pubmed/29490689
http://dx.doi.org/10.1186/s13048-018-0392-1

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