Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase

The rise of drug-resistant influenza A virus strains motivates the development of new antiviral drugs, with different structural motifs and substitution. Recently, we explored the use of a bicyclic (bicyclo[3.1.0]hexane) analogue of sialic acid that was designed to mimic the conformation adopted dur...

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Detalles Bibliográficos
Autores principales: Colombo, Cinzia, Podlipnik, Črtomir, Lo Presti, Leonardo, Niikura, Masahiro, Bennet, Andrew J., Bernardi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831633/
https://www.ncbi.nlm.nih.gov/pubmed/29489903
http://dx.doi.org/10.1371/journal.pone.0193623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831633/
https://www.ncbi.nlm.nih.gov/pubmed/29489903
http://dx.doi.org/10.1371/journal.pone.0193623

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