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Optimizing homeostatic cell renewal in hierarchical tissues

In order to maintain homeostasis, mature cells removed from the top compartment of hierarchical tissues have to be replenished by means of differentiation and self-renewal events happening in the more primitive compartments. As each cell division is associated with a risk of mutation, cell division...

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Detalles Bibliográficos
Autores principales: Alvarado, Cesar, Fider, Nicole A., Wearing, Helen J., Komarova, Natalia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831642/
https://www.ncbi.nlm.nih.gov/pubmed/29447149
http://dx.doi.org/10.1371/journal.pcbi.1005967