The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Recent studies with cell lines show that CES2 expression is regulated by the tumor suppressor protein p53. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishimine, Momoko, Lee, Hyeon-Cheol, Nakaoka, Hirofumi, Orita, Hajime, Kobayashi, Toshiyuki, Mizuguchi, Konomi, Endo, Mikumi, Inoue, Ituro, Sato, Koichi, Yokomizo, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831679/
https://www.ncbi.nlm.nih.gov/pubmed/29651325
http://dx.doi.org/10.1155/2018/5280736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831679/
https://www.ncbi.nlm.nih.gov/pubmed/29651325
http://dx.doi.org/10.1155/2018/5280736

Ejemplares similares