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Structural Basis for pH-Dependent Oligomerization of Dihydropyrimidinase from Pseudomonas aeruginosa PAO1

Dihydropyrimidinase, a dimetalloenzyme containing a carboxylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase. Unlike all known dihydropyrimidinases, which are tetrameric, pseudomonal dihyd...

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Detalles Bibliográficos
Autores principales: Cheng, Jen-Hao, Huang, Chien-Chih, Huang, Yen-Hua, Huang, Cheng-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832032/
https://www.ncbi.nlm.nih.gov/pubmed/29666631
http://dx.doi.org/10.1155/2018/9564391