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PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia
Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. I...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832124/ https://www.ncbi.nlm.nih.gov/pubmed/29636835 http://dx.doi.org/10.1155/2018/1364165 |