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Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes

The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediat...

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Autores principales: Fuyuno, Yoko, Uchi, Hiroshi, Yasumatsu, Mao, Morino-Koga, Saori, Tanaka, Yuka, Mitoma, Chikage, Furue, Masutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832143/
https://www.ncbi.nlm.nih.gov/pubmed/29643980
http://dx.doi.org/10.1155/2018/9524657
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author Fuyuno, Yoko
Uchi, Hiroshi
Yasumatsu, Mao
Morino-Koga, Saori
Tanaka, Yuka
Mitoma, Chikage
Furue, Masutaka
author_facet Fuyuno, Yoko
Uchi, Hiroshi
Yasumatsu, Mao
Morino-Koga, Saori
Tanaka, Yuka
Mitoma, Chikage
Furue, Masutaka
author_sort Fuyuno, Yoko
collection PubMed
description The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress.
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spelling pubmed-58321432018-04-11 Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes Fuyuno, Yoko Uchi, Hiroshi Yasumatsu, Mao Morino-Koga, Saori Tanaka, Yuka Mitoma, Chikage Furue, Masutaka Oxid Med Cell Longev Research Article The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress. Hindawi 2018-02-14 /pmc/articles/PMC5832143/ /pubmed/29643980 http://dx.doi.org/10.1155/2018/9524657 Text en Copyright © 2018 Yoko Fuyuno et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fuyuno, Yoko
Uchi, Hiroshi
Yasumatsu, Mao
Morino-Koga, Saori
Tanaka, Yuka
Mitoma, Chikage
Furue, Masutaka
Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
title Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
title_full Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
title_fullStr Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
title_full_unstemmed Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
title_short Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
title_sort perillaldehyde inhibits ahr signaling and activates nrf2 antioxidant pathway in human keratinocytes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832143/
https://www.ncbi.nlm.nih.gov/pubmed/29643980
http://dx.doi.org/10.1155/2018/9524657
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