Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein

Werner syndrome (WS) is a premature aging disorder caused by mutations in a protein containing both a DNA exonuclease and DNA helicase domain. Mice lacking the helicase domain of the Wrn protein orthologue exhibit transcriptomic and metabolic alterations, some of which are reversed by vitamin C. Rec...

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Detalles Bibliográficos
Autores principales: Aumailley, Lucie, Roux-Dalvai, Florence, Kelly, Isabelle, Droit, Arnaud, Lebel, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832228/
https://www.ncbi.nlm.nih.gov/pubmed/29494634
http://dx.doi.org/10.1371/journal.pone.0193170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832228/
https://www.ncbi.nlm.nih.gov/pubmed/29494634
http://dx.doi.org/10.1371/journal.pone.0193170

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