Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo

The Kelch-like erythroid-associated protein 1 (Keap1)–NF-E2-related factor 2 (Nrf2) signaling pathway is the subject of several clinical trials evaluating the effects of Nrf2 activation on the prevention of cancer and diabetes and the treatment of chronic kidney disease and multiple sclerosis. 3H-1,...

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Detalles Bibliográficos
Autores principales: Wible, Ryan S., Tran, Quynh T., Fathima, Samreen, Sutter, Carrie H., Kensler, Thomas W., Sutter, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832324/
https://www.ncbi.nlm.nih.gov/pubmed/29367259
http://dx.doi.org/10.1124/mol.117.110262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832324/
https://www.ncbi.nlm.nih.gov/pubmed/29367259
http://dx.doi.org/10.1124/mol.117.110262

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