p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we...

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Detalles Bibliográficos
Autores principales: Roy, Sunetra, Tomaszowski, Karl-Heinz, Luzwick, Jessica W, Park, Soyoung, Li, Jun, Murphy, Maureen, Schlacher, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832412/
https://www.ncbi.nlm.nih.gov/pubmed/29334356
http://dx.doi.org/10.7554/eLife.31723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832412/
https://www.ncbi.nlm.nih.gov/pubmed/29334356
http://dx.doi.org/10.7554/eLife.31723

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