TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

The best characterized signaling pathway downstream of transforming growth factor β (TGF-β) is through SMAD2 and SMAD3. However, TGF-β also induces phosphorylation of SMAD1 and SMAD5, but the mechanism of this phosphorylation and its functional relevance is not known. Here, we show that TGF-β-induce...

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Detalles Bibliográficos
Autores principales: Ramachandran, Anassuya, Vizán, Pedro, Das, Debipriya, Chakravarty, Probir, Vogt, Janis, Rogers, Katherine W, Müller, Patrick, Hinck, Andrew P, Sapkota, Gopal P, Hill, Caroline S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832415/
https://www.ncbi.nlm.nih.gov/pubmed/29376829
http://dx.doi.org/10.7554/eLife.31756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832415/
https://www.ncbi.nlm.nih.gov/pubmed/29376829
http://dx.doi.org/10.7554/eLife.31756

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