A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal

A key constraint in genomic testing in oncology is that matched normal specimens are not commonly obtained in clinical practice. Thus, while well-characterized genomic alterations do not require normal tissue for interpretation, a significant number of alterations will be unknown in whether they are...

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Detalles Bibliográficos
Autores principales: Sun, James X., He, Yuting, Sanford, Eric, Montesion, Meagan, Frampton, Garrett M., Vignot, Stéphane, Soria, Jean-Charles, Ross, Jeffrey S., Miller, Vincent A., Stephens, Phil J., Lipson, Doron, Yelensky, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832436/
https://www.ncbi.nlm.nih.gov/pubmed/29415044
http://dx.doi.org/10.1371/journal.pcbi.1005965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832436/
https://www.ncbi.nlm.nih.gov/pubmed/29415044
http://dx.doi.org/10.1371/journal.pcbi.1005965

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