Phase-plate cryo-EM structure of a class B GPCR-G protein complex

Class B G protein-coupled receptors are major targets for treatment of chronic diseases, including osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Gαβγs protein determined b...

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Detalles Bibliográficos
Autores principales: Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M, Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K, Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832441/
https://www.ncbi.nlm.nih.gov/pubmed/28437792
http://dx.doi.org/10.1038/nature22327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832441/
https://www.ncbi.nlm.nih.gov/pubmed/28437792
http://dx.doi.org/10.1038/nature22327

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