PO and ID BCG vaccination in humans induce distinct mucosal and systemic immune responses and CD4+ T cell transcriptomal molecular signatures

Protective efficacy of Bacillus Calmette-Guérin (BCG) may be affected by the methods and routes of vaccine administration. We have studied the safety and immunogenicity of oral (PO) and/or intradermal (ID) administration of BCG in healthy human subjects No major safety concerns were detected in the...

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Detalles Bibliográficos
Autores principales: Hoft, DF, Xia, M, Zhang, GL, Blazevic, A, Tennant, J, Kaplan, C, Matuschak, G, Dube, TJ, Hill, H, Schlesinger, LS, Andersen, PL, Brusic, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832504/
https://www.ncbi.nlm.nih.gov/pubmed/28853442
http://dx.doi.org/10.1038/mi.2017.67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832504/
https://www.ncbi.nlm.nih.gov/pubmed/28853442
http://dx.doi.org/10.1038/mi.2017.67

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